This study deals with the machining of sculptured surfaces on 5-axis CNC milling machine with end mill cutter. The study (I) has the following contents. In 5-axis CNC milling, CL-data consist of CC-data and cutter axis direction vector at the CC-point. Thus, in machining of the sculptured surface on 5-axis CNC milling machine, determination of the direction vector of the milling cutter is very important. The direction vector is obtained by the fact that bottom plane of the milling cutter must not interfere with the free-form surface being machined. The interference is checked by the z-map method which can be applied in all geometric types of the sculptured surfaces. After generating NC part programs from 5-axis post-processing algorithms, sculptured surfaces were machined with 5-axis CNC milling machine (CINCINNATI MILACRON, 20V-80). From these machining tests, it was shown that the machining of the free-form surfaces on 5-axis CNC milling machine with the end mill has smaller cusp heights and shorter cutting time than on 3-axis CNC milling machine with the ball-end mill. Thus, 5-axis CNC end milling was effective machining method for sculptured surfaces. The study (II) deals with the prediction of cusp height and the determination of tool path interval for the 5-axis machining of sculptured surfaces on the basis of study(I).