These studies were carried out to investigate the effects of ascorbate and $alpha$-tocopherol administration on the biochemical parameters of liver function and hydroperoxidation in liver of chronically ethanol-treated rats. Forty healthy Sprague-Dawley (SD) rats weighing about 120g were used for this experiment and divided into the following 5 groups: control group (CON), ethanol control group (ECON), ascorbate treated group (EASC), $alpha$-tocopherol treated group (ETOC) and ascorbate.$alpha$-tocopherol mixture treated group(EASC + ETOC). Ethanol was administered orally by 5ml per kg, body weight per day for 8weeks. Antioxidants treated groups were administered orally by 5mg per kg body weight per day in saline solution for 3 weeks. Lipid hydroperoxides were analyzed by using chemiluminescense-high performance liquid chromatography (CL-HPLC) method phosphatidylcholine hydroperoxide value (PCOOH) in liver tissues. Ethanol treatment significantly (p<0.05) resulted in an increase in GPT and GOT activities and liver hydroperoxide values comparing with the untreated control, while administration of $alpha$-tocopherol and ascorbate+$alpha$-tocopherol to the chronically ethanol-treated rats significantly (p<0.001) decreased GPT and GOT activities and liver hydroperoxide value. These results indicate that dietary $alpha$-tocopherol and $alpha$-tocopherol combined with ascorbate administration may inhibit the formation of liver lipid hydroperoxidation in vivo and were very effective in recovering the liver function in chronically ethanol-treated rats.