Time domain analysis as well as frequency domain analysis of signal conditioning filters is very useful for practical applications. Time domain analysis of digital filters for noise cancelling in ECG signals is presented. Several band pass and band reject filters are designed for the analysis. Computer simulations are performed to compare the distortions of the Butterworth type filters and linear phase optimal FIR filters which are widely used for ECG signal processing. Band reject filters are applied to power line interference cancelling in ECG signals.