The purpose of this study was to evaluate the effects of Vitapex on the periapical lesions. Thirteen single-rooted teeth from ten patients who visited the SNU hospital were endodontically treated with Vitapex and Gutta percha cone, and radiographically and clinically evaluated for a period of 1 to 6 months. The results were as follows : 1. The loss of clinical symtoms was observed in all 13 teeth. 2. The reduction of size of periapical lesions in radiographs was observed in 10 teeth. The periapical lesions of remaining 3 teeth also look better in the radiographs. 3. All 13 teeth showed the reduction of radiolucency. 4. The gradual resorption of Vitapex over the root apex was observed.