The pathological basis for cervicogenic headache may lie within the cervical spine. Clinically patients with cervicogenic headache complain of unilateral pain radiating in an atypical fashion from the occipital region. Our clinic has successfully treated post-traumatic cervicogenic headache with C2 spinal ganglion block. The technique of fluoroscopic guided injection was used to locate the C2 spinal ganglion. This technique is facilitated by the constancy of the anatomical relationship between the C2 ganglion and the midpoint of the atlanto-axial joint. There are no major structures near the proximity of the ganglion.