Inclusion complexes of ketoconazole(KT) with ${alpha}^_$, ${eta}^_$cyclodextrin(CD) and $dimethy1-{eta}-cyclodextrin$ (CD) and $dimethy1-{eta}-cyclodextrin(DM{eta}CD)$ as nasal absorption enhancer were prepared in 1: 2 molar ratios by freeze-drying and solvent evaporation methods. In order to compare with the intrinsic absorptivity of KT in the jejunum(J) and the nasal cavity(N), the in situ simultaneous perfusion method was employed. The in situ recirculation study revealed that KT-CD inclusion complexes with the greater stability constant and the faster dissolution rate proportionally increased the absorption of KT in the J and N of rats. The rank order of apparent KT permeability$(P_{app};:;cm/sec;{ ime};1O^{-5}{pm}S.E.)$, corrected by surface area of absorption, was $5.10{pm}0.3(N,; KT-DM{eta}CD)$ )> $4.13{pm}0.4(N,;KT-{eta}-CD)$ )> $3.52{pm}0.2(N,;KT-{alpha}-CD)$ )> $2.76{pm}0.3(J,; KT-DM{eta}CD)$ )> $2.61{pm}0.5(J,;KT-{eta}-CD)$ )> $2.42{pm}0.4(J,;KT-{alpha}-CD)$ at pH 4.0. The in crease in permeability of $KT-DM{eta}CD$ inclusion complex was 2.6 folds in the J and 4.5 folds in the N when the perfusing solution was changed from the buffer(pH 4.0) to saline. The absorption rate of $KT-DM{eta}CD$ inclusion complex after nasal administration was more rapid than those of ketoconazole alone and $KT-DM{eta}CD$ inclusion complex after oral administration to rats. In comparision with an oral administration of ketoconazole suspension in corn oil, the relative bioavailability was calculated 137.3% for the oral and 195.0% for nasal $KT-DM{eta}CD$ inclusion complex in rats. The present results suggest that $KT-DM{eta}CD$ inclusion complex may serve as a potential nasal absorption enhancer for the nasal delivery of ketoconazole.