The purpose of this study was to investigate the glucose and lipid metabolic changes physical exercise of patients with NIDDM. The physical exercise consisted of 15 minutes per day on a bicycle ergometer at $70\%$ maximum heart rate. The results of this study which were calculated from the level of glucose and lipid metabolism of the preexercise and after 2weeks exercise were as follows. 1. Blood glucose was siginificiantly decreased after physical exercise of two weeks(P<0.005). 2. Total cholesterol showed a tendency to decrease after physical exercise of two weeks, but the difference was statistically insignificiant. 3. Triglyceride showed a tendency to decrease on female, but triglyceride on man was inclose after exercise. 4. HDL showed a tendency to increase after physical exercise of two weeks, but the results were statistically insigificiant. 5. LDL showed a tendency to decrease after physical exercise of two weeks, but the results were statistically insignificiant. 6. HDL/cholesterol showed a tendency to increase aftre physical exercise of two weeks, but the results were statistically insignificiant.