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12-Arm Radial Maze를 이용한 쥐의 공간 인지능력에 미치는 홍삼 PT계 사포닌의 효과
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  • 12-Arm Radial Maze를 이용한 쥐의 공간 인지능력에 미치는 홍삼 PT계 사포닌의 효과
저자명
박진규,남기열
간행물명
고려인삼학회지
권/호정보
1994년|18권 1호|pp.32-38 (7 pages)
발행정보
고려인삼학회
파일정보
정기간행물|
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이 논문은 한국과학기술정보연구원과 논문 연계를 통해 무료로 제공되는 원문입니다.
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기타언어초록

Male rats aged 15 months, which had been over-trained with 12 arm radial maze up to the criterion of 1 or 2 errors an average per trial, were divided into two groups and 7 months after the over-training and were studied the effect of red ginseng trial saponin fraction (PT) on the spatial memory function. The rats which could be improved the performance of 9.75$pm$1.26 (within 185$pm$8.2 1 sec) were classified into "normal group" (n=4) and the ones, which showed R-maze performance of 7.0$pm$2.87 within 300 sec, "deteriorated memory group" (n=5). PT was dissolved in distilled water and injected into the deteriorated memory group intraperitoneally at 30 min before R-maze for 3 consecutive days. The injected amount of PT on the 1st day was 10mg/rat, 1mg/rat both on the 2nd the 3rd day. As results, the performance was restored to 9.4$pm$2.0 after stopping ginseng administration, although the lower performance values (1.4$pm$0.89, 2.8$pm$0.83, 3.8$pm$0.84, respectively) were exerted during the three days of PT administration than before PT administration (7.0$pm$2.87) since 1 day after administratitan of PT. The restored performance values were continuously maintained up to the level of the "normal group". However, any lower performance values were not observed when PT was administered via intraperitoneal route to the normal group in about of 2 mg/rat except 10mg1ra1. The number of errors when the foods in arms were put at only 6 places was clearly reduced during the 9 days of consecutive administration of PT as compared with untreated control. These results indicated that PT administration may enhance their cognitive function after a long lapse of time not only in the memory deteriorated rats but also in normal ones. The reason exerted lower performance values during PT administration in this paper was discussed as compared with the results of T-maze behavior of another 3-month-aged rats. of another 3-month-aged rats.