This study presents thickness optimization for the pressure vessel domes subject to internal pressure and axial force simultaneously. The considered typical pressure vessel domes are ellipsoidal and tori-spherical domes with skirt and nozzle part. These pressure vessel domes under loading have higher stress concentration on geometric discontinuity parts. Therefore, thickness optimization of axi-symmetric pressure vessel domes is essentially concerned on minimizing this stress concentration. The objective function is minimization of weight of pressure vessel dome. The design variable is thickness of dome and cylinder. Considered constraint is Von Mises equivalent stress. In the optimization procedure, ANSYS code is used. The equivalent and hoop stress of original shape domes are compared with those of optimal shape domes. And optimal thicknesses for pressure vessel domes are presented.