A variable structure control scheme(VSCS) with sliding mode that can be applied to the process with input/output(I/O) delay is proposed and its control performances is evaluated. The proposed VSCS with and output feedback scheme comprises a variable structure controller, a servo dynamic for tracking the set-poing, and a Smith predictor for compensating the effects of time delay. The robustness against the parameter variations and external disturbances can be achieved by the proposed VSCS even when the controlled process includes I/O delay. And the desired transient response is obtained by simple adjustment of the coefficients of the switching surface equation.