For the identification of the optimal operating conditions of phosphoric acid plant, an intelligent simulation was performed based on the dissolution reaction of phosphate rock. A phosphoric acid plant consists of three main processes : ball-mill grinding process, rock reaction process and slurry filteration process. The grinding and filteration processes are relatively simple processes and most of the simulation works are on the reaction process. The practical operation data of phosphoric acid plant at Namhae Chemical Corp. were utilized in the simulation. The operation of the phosphoric acid plant is highly dependent on the heuristics of operators and so the expert system technology was employed. The operation of phosphoric acid plant varies with the origin of phosphate rock. Results of the simulation showed the optimal values of major process variables and optimal operating conditions. The knowledgebase for the expert system was constructed based on the interview with the experienced plant operators.