This study was carried on to investigate the effect of physiological significance of hand and foot on thermoregulation and thermal pleasantness in clothed $mu$ Oral and skin temperatures after immersing hands and feet in the cold or the warm water at Ta of 25 and $20^{circ}C$, respectively, were compared with four types of garment worn by two healthy male subjects. Four types of gannent expressed as A, B, C, D, were determined by the exposed areas of extremities : hands only are exposed in A, feet only are exposed in B, both hands and forearms are exposed in C, and both feet and legs are exposed in D. Major findings observed reveals that oral temperatures in D were generally maintained higher than those in A, B, and C. This is probably because the size of exposed areas rather than skin temperatures seem to determine the level of core temperature. Also, obtained result that thermal sensations felt by the subjects in foot are more closely related to local skin temperatures when they are compared to those in hand. From these findings it would be suggested that the significance of hand and foot in temperature regulation appears to be connected more with behavioral than with physiological.