The purpose of this study was to establish a baseline in order that individuals may exercise safely. Sixty healthy students who were divided into two groups participated in the experiment. One group exercised both arms and legs at 60 rpm and the other at 90 rpm. There was a significant difference between arm and leg exercise in diastolic blood pressure (DBP) and time to target heart rate (tTHR). DBP decreased more in the upper (U//E) than the lower extremity (L/E), but tTHR increased more in the L/E than the U/E (p < 0.05). Systolic blood pressure (SBP) was similar for both arm and leg exercise (p > 0.05). There was also no significant difference between 60 rpm and 90 rpm in SBP, DBP or tTHR in either arm or leg exercise (p > 0.05). In conclusion, the slope of the linear increase in heart rate was steeper for U/E than L/E work. Therefore L/E exercise is safer than U/E exercise.