Phytochemical study on the aerial parts of Solanum lyratum (Solanaceae) was carried out. On the basis of phytochemical and spectroscopic evidences, compound I was identified as mixtures of hexadecanoic acid methyl ester, 2,6,10,15-tetramethyl heptadecane, tricosane, tetracosane, pentacosane, docosanoic acid methyl ester, docosane, tricosanoic acid methyl ester, 8-hexyl pentadecane, tetracosanoic acid methyl ester, pentatriacontane, hexatriacontane, eicosane, hexacosane, hentriacontane and stigmasta-5,23-dien $3-{eta}-ol$, and compound II, III, IV and V were identified as hexacosanoic acid methyl ester, ${eta}-sitosterol-{eta}-{_D}-glucoside$, $3-O-{alpha}-{_L}-rhamnopyranosyl-(1->2)-{eta}-{_D}-glucuronopyranosyl$ diosgenin and $3-O-{alpha}-{_L}-rhamnopyranosyl-(1->6)-{eta}-{_D}-glucopyranosyl$ quercetin (rutin), respectively. Rutin was identified as one of the active principles having antioxidative effect from S. lyratum.