The experimental studies were done to research the clinical effects of lnsambaekhabtang and Insambaekhabtanggamibang on the xylene-poisoned-lung damage and hypoprothrombinemia induced by warfarin injection in rats and mice. The results are as follows: 1. As to the hemostatic time in mice, lnsambaekhabtang was recongnized no significance but Insambaekhabtanggamibang was recognized significance( P<0.02 ). 2. As to the prothrombine time in rats. lnsambaekhabtang and lnsambaekhabtanggamibang Were recognized significance ( P<0.05, P<0.05 ). 3. As to the recalcification in rats, Insambaekhabtang and lnsambaekhabtanggamibang Were recognized significance ( P<0.05, P<0.02). 4. As to the lung TBA values in Xylene intoxicated rats, Insambaekhabtang was recognized significance but Insambaekhabtanggamibang was no recognized significance ( P<0.05). 5. As to the oxygen consumption in Xylene intoxicated rats, Insambaekhabtang and lnsambaekhabtanggamibang were no recognized significance. According to the above findings, it is suggested that the solid extract of Insambaekhabtang and Insambaekhabtanggamibang revealed effects on the xylene-poisoned-Iung damage and hypoprothrombinemia induced by warfarin injection in rats and mice.