Purpose : The purpose of this study was to evaluate the short and long-term effectivensess of intracavitaryurokinase with percutaneous catheter drainage in loculated thoracic empyemas. Materials and Methods : 15 patientswere identified as second stage of loculated thoracic empyema by estimating nature of pleural fluid, chest PA, lateral decubitus view and CT scan. Under the guidance of fluoroscopy or ultrasound, catheter was insertedpercutaneously. Instillation of urolinase with 100ml of normal saline. Trial of urokinase was repeated untilcomplete drainage of empyema was demonstrated on plain chest film obtained after 48 hours. Results : Successfulcomplete drainage was achieved in 14 of 15 patients. Average dosage of used urokinase was 330, 000U and meanduration of catherter insertion was 35 days. Conclusion : Intracavitary urokinase with percutaneous catheterdrainage is a safe and effective method to facilitate drainage of loculated empyema and to prevent recurrence.