Purpose : The purpose of this study is to analyze the CT features of the cystic masses in the neck and toreview differential diagnosis. Materials and Methods : We retrospectively reviewed and analyzed the CT findings of22 histopathologically proved, cystic neck masses in regard to the locations in fascial plane and relationshipwith adjacent organ. Results: Of 22 cases, ten congenital cystic two ranulas, seven inflammatory lesions, andthree solid tumors were includded. Ten congenital cystic masses were located in typical locations as branchialcleft cyst(5) in mandibular angle, thyroglossal duct cyst(3) in visceral space embeded within the strap muscles, cystic hygroma(1) and cavernous hemangioma(1) in posterior cervical space with insinuating appearance. Two casesof ranulas included one simple ranula localized in sublingual space and a plunging ranula extended to adjacentsubmandibular space. Seven cases of inflammatory lesions were characterized by multispatial locations and goodcontrast-enhancement of walls and adjacent tissue. Solid masses of low density mimicking cyst were two pleomorphicadenoma of submandibular gland and one neurilemmoma. Conclusion : It is considered that thorough analysis of theCT findings with attention to typical location, CT appearance, and the relationship with the adjacent structuresusually leads to the correct diagnosis.