Percutaneous aspiration needle biopsy of the intrathoracic disease is a safe, easy, and accurate diagnosticmethod. It usually causes mild pain or discomfort during the procedure. We had a patient who complained of severesharp pain, well localized at the biopsy site of the target mass during CT-guided transthoracic aspiration biopsy.It was pathologically confirmed as an intrathoracic schwannoma after special staining. To our knowledge, there hasbeen no published report of such a painful percutaneous needle biopsy in a patient with schwannoma in Korea. Twocases were reported in other radiologic journals. The severe sharp pain developed during the transthoracicaspiration needle biopsy is a reliable sign of neurogenic tumor, therefore the participating radiologist shouldrecommend specific immumochemical stain for neurogenic tumor to pathologist.