- 아스파라톤에 의한 사이클로옥시게나제의 저해 - in Vitro
- In Vitro Inhibition of Cyclooxygenase by Aspalatone
- ㆍ 저자명
- 서대연,한병훈
- ㆍ 간행물명
- 약학회지
- ㆍ 권/호정보
- 1995년|39권 5호|pp.565-568 (4 pages)
- ㆍ 발행정보
- 대한약학회
- ㆍ 파일정보
- 정기간행물| PDF텍스트
- ㆍ 주제분야
- 기타
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A new antiplatelett agent, aspalatone ([3-(2-methyl-4-pyronyl)]-2-acetyloxybenzoate) was demonstrated to inhibit MDA generation from arachidonic acid catalyzed by partially purified bovine seminal vesicle cyclooxygenase. This inhibition was also observed with acetylsalicylic acid. The results suggest that the mechanism for the antiplatelet effect of aspalatone is, like acetylsalicylic acid, due to its inhibition of cyclooxygenase.