This study was carried out in order to compare the methods for Salmonella spp. isolation from sewage and to settle the most appropriate conditions for that isolation. The direct enrichment method was more effective than the pre- enrichment method for Salmonella spp. isolation. The rate of detection was much higher when the specimens were enriched at $41.5^{circ}C$ than when at $35^{circ}C$. Usage of XLBG agar medium showed better results for Salmonella isolation than that of SS medium. It can be suggested that the most effective combination for Salmonella spp. isolation was the direct centrifugation(3,000 rpm 100m1)- direct enrichment($41.5^{circ}$C)-usage of XLBG medium.