The purpose of this study is to develop the technique of energy recovery and energy saving by using the optimization of heat exchanger network synthesis. This article proposes a new method of determining the optimal target of a heat exchanger network synthesis problem of which data feature multiple pinch points. The system separation method we suggest here is to subdivide the original system into independent subsystems with one pinch point. The optimal cost target was evaluated and the original pinch rules at each subsystem were employed. The software developed in this study was applied to the Alko prosess, which is an alcohol production process, for the synthesis of heat exchanger network. It was possible to save about 15% of the total annual cost.