A practical application of a fuzzy-neuro controller is described for an air-conditioning system. Air-handing units are being widely used for improving the performance of central air-conditioning systems. The fuzzy-neuro control system has two controlled variables, temperature and humidity and three control elements, cooling, heating, and humidification. In order to achieve high efficiency and economical contorl, especially in large offices and industrial buildings, two controllable parameters, temperature and humidity, must be adequately controlled by the three final controlling elements. In this paper a fuzzy-neuro control system is described for controlling air-conditioning systems efficiently and economically. Simulation results confirmed that the fuzzy neuro control system is effective for this multivariable system.