- 산조인 알카로이드의 가용화 및 물성에 관한 연구
- ㆍ 저자명
- 서광교,이치호,Sheu. Kwang-Gyou,Lee. Chi-Ho
- ㆍ 간행물명
- 藥劑學會誌
- ㆍ 권/호정보
- 1996년|26권 4호|pp.257-261 (5 pages)
- ㆍ 발행정보
- 한국약제학회
- ㆍ 파일정보
- 정기간행물| PDF텍스트
- ㆍ 주제분야
- 기타
The seeds of Zizyphus Jujuba have been used as an antianxiety agent for the treatment of insomnia from the earliest times. Sanjoinine-A, isolated from the seeds of Zizyphus Jujuba, have been found to have a minor tranquilizer activity. However this drug is poorly soluble in water. In order to increase the dissolution rate of sanjoinine-A, solid dispersions with PVP-MC and inclusion complex with ${eta}-cyclodextrin$ were prepared and evaluated. All of these systems increased the dissolution rate of sanjoinine A comparing with sanjoinine-A free base. From pH-rate profile of sanjoinine-A at $60^{circ}C$, it was found that sanjoinine A was relatively stable in acidic solution, but unstable in basic solution.