In order to investigate the effects of api-toxin therapy on depression of immune response, mice were exposed to cold stress $(-20^{circ}C)$) in 30 minutes twice a day and api-toxin(Bee Venom from Korea and U.S.A) therapy was treated to the Kihae $(CV_6)$ locus of human body every two days with 4 sessions of treatment for 8 days. The mice were sensitized i.v. with $5{ imes}10^8$ sheep red blood cells (SRBC) on the 4th day and challenged i.d. with $2{ imes}10^9$ SRBC 4 days later. Immune Response for delayed type hypersensitivity (DTH), lympocyte transformation(LTT), hemolysin titer(HL), plaque forming cells (PFC) were measured.