Sangphisan, sangphisan with Cortex Mori Cortex Lycii, Semen Lepidh were administrated into rats and then they were injected by Paraquat. The results are as follows 1. After 72 hours following the injection of paraquat, the survival rate of rats increased Sangphisan, Sangphisan with Cortex Mori Cortex Lycii Group. 2. Respirayory rates of rats witch survived 72 hours later significantly decreased in sangphisan, sangphisan with Semen Lepidh. 3. Lung weights of rats which survived for 72 hours later significantly decreased in Sangphisan, Sangphisan with Cortex Mori Cortex Lycii and mild decreased in Sangphisan with Semen Lepidh. 4. After the injection of paraquat, a lung tissue showed severe hemorrhage, edema and some broken aibeoli and Sangphisan, sangphisan with Cortex Mori Cortex Lycii, Sangphisan with Semen Lepidh recovered significantly.