This study was performed to investigate the effect of red ginseng extract including some vitamin B groups as test drug on learning and memory in mice. Single and repeated administrations of the test drug improved the acquisition and the process of consolidation in the tests using step-through and step-down apparatus, indicating this test drug improved learning and memory. However, the test drug did not improve scopolamine-induced amnesia. These results suggest that test drug may be useful as a nootropic agent