Purpose : To evaluate the usefulness of the esophagogram using marshmallow bolus in the evaluation of thecauses of variable esophageal-related symptoms. Materials and Methods : Esophagograms using marshmallow bolus wereperformed on 44 patients with esophageal-related symptoms and on ten normal volunteers. Videofluoroscopic studieswere also made. Patients were classified into three groups according to their esophageal-related symptoms ; thosewith dysphagia, those with globus symptom, and those with chest pain. Abnormal findings on an esophagogram withmarshmallow were graded into three categories ; mild, moderate, and severe. Provocation of the same symptom wasalso evaluated. Esophageal manometric studies were performed on 16 patients and those results were compared withthe results obtained from the esophagogram using marshmallow bolus. Results : The provocation rate of the samesymptom was 33% in the first group, 47% in the second, and 24% in the third. The provocation rate was highest inthe second group. The provocation rate was also higher in patients with a severe degree of abnormality on anesophagogram using marshmallow bolus. Where there were abnormal findings, an esophagogram using marshmallow bolusshowed a higher abnormality rate than did a conventional esophagogram. In cases showing abnormal findings on theesophageal manometric study, an esophagogram using marshmallow bolus showed a higher provocation rate and moresevere abnormality than in cases showing normal findings on manometric study. Conclusion : An esophagogram usingmarshmallow bolus will a useful radiologic screening modality for the evaluation of patients withesophageal-related symptoms.