An analysis of convective boiling heat transfer for refrigerant mixtures is performed for an annular flow to investigate the degradation of the heat transfer rate. Annular flow is selected in this study because a great portion of the evaporator in the refrigeration and air conditioning system is known to be in the annular flow regime. Mass transfer effect due to composition difference between liquid and vapor is included in this analysis, which is considered to be one of driving forces for the mass transfer at the interface. Due to the concentration gradient at the interface the mass transfer is interfered, so is the evaporative heat transfer at the interface. The mass transfer resistance makes the interface temperature slightly higher and, as a result, the heat transfer coefficients decrease compared with those without mass transfer effects. The degradatioin of the heat transfer rate reaches its maximum at a certain composition. The composition difference between vapor core and vapor at the interface has a direct effect on the temperature difference between the vapor core and the interface and the degradation of the heat transfer rate. Correction factor $C_{F}$ for the mixture effects is added to the correlation for pure substances and the flow boiling heat transfer coefficients can be calculated using the modified equation.n.