Estimation and removal procedures for baseline drift have been developed using linear, cubic spline, and bilineared transformed high pass filter. Linear and cubic spline interpolation with the PQ and TP segmens, which are considered to be isoelectric, as fiducial points ahve been estimated respectively. For a quantitative validation of the estimation procedure, 4 ECGs with arfificial baseline drift were constructed and analyzed by mean square error calculations and amplitude histograms. Also real ECGs were analyzed in a test set of the CSE data set 3 and set 4. Baseline drift detecton rule were designed and new method for the decision of fiducial point were constructed to avoid distorting as the case of premature ventricular or atrial contraction. From these comparison, proposed cubic spline method with PQ and TP segment (CS_PQ & TP) emerged as the most efficient method.