Air space disorders are usually considered medical diseases, although some patients with air space disorders can benefit from surgical intervention. Recently we experienced two cases of bullous emphysema. One case is large bilateral apical bullae and the other is infected large bulls of RUL with bullous emphysema. The patient with large bilateral apical bullae underwent simultaneous operation via bilateral thoracotomy and other patient underwent simultaneous bilateral operation via median sternotomy. Postoperatively, the patient with large bilateral apical bullae showed subjective as well as objective improvement and other patient is resulted subjective improvement.