Pipe design normally requires pump power, discharge or pipe diameter for each condition given. Due to several investigators the pipe friction factor con now be estimated by explicit way for a wide range of flow condition. In various problems of pipe design, however, the flow condition cannot be pre-determined even for a uniformly rough pipe. In these cases a lot of iterations are often required to have an accurate solution with ordinary approach. This paper presents the direct computation method of discharge and pipe diameter without any iteration process. Introducing the power law of friction factor, various non-dimensional physical numbers are derived such as power-diameter number, power-discharge number, diameter-slope number and discharge-slope number. One of the physical numbers concerned with discharge or pipe diameter can be related to a combination of the other in an explicit way.