1-phenylpyrrolidine-2,5-diones에 대한 형태분석을 통하여 구조-활성 상관관계를 검토하였다. Antifungel activity에 대한 구조적인 특징으로 활성기인 imide group(-NCO)와 벤젠 moity가 존재하며, 강한활성을 나타내는 유사체의 N원자와 치환기간의 공간거리 N-X4는 5.318~5.320 ${AA}$, 3,5-치환기간의 거리 X3 -X5는 5.437∼6.072 ${AA}$을 나타내었다. 또한 여러 파라미터가 검토되었다.
The relationship between chemical structure and antifungal activity of benzene ring substituents of 1-phenylpyrrolidine-2,5-diones is studied by testing of model compounds and use of conformational data. The analysis revealed a number of structural features as essential for the antifungal effect: (1) the presence of an intact-NCO group and benzene moiety; (2) the distance between para substituents and the N atom within the 5.318∼5.320 ${AA}$ range; (3) the distance between substituent X3 and X5 in the interval 5.437∼6.072 ${AA}$ for the active analogues. And other parameters were discussed.
