PALMIWON is composed of 8 oriental herbs which has been known to show some pharmacological effects in kidney, blood vessels and immune systems, and used for the treatment of kid ney disease, hypertension, nervous disease and diabetic mellitus in the Orient for a long time. Based on our previous report that PALMIWON showed different effects on immune cells and ${eta}$-cells, the immunoreactivity of ICSA (Islet Cell Surface Antibody) with ${eta}$-cell (RINm5F) and the cell proliferation and function of interleukin-1${eta}$ damaged ${eta}$-cells in the presence of PALMIWON were examined. It was observed that PALMIWON significantly inhibited the immunoreactivity of ICSA with ${eta}$-cell, and markedly increased cell proliferation and insulin release of interleukin-1${eta}$ damaged ${eta}$-cells.