The studies on the detoxification of paralytic shellfish poison (PSP)-infested blue mussels, Mytilus edulis and oyster, Crassostrea gigas were performed for using of available processing resource. Toxic blue mussel and oysters from Nampo in Masan Bay, Hachong in Koje Bay and Woepori in Koje were used for experimental samples. The toxicity of low toxic blue mussel $(A,;84{mu}g/100g;;B,;166{mu}g/100g;;C,;295{mu}g/l00g;;D,;557{mu}g/100g)$ and oyster $(740{mu}g/100g)$ were reduced below the regulation limit of PSP $(80{mu}g/100g)$ or undetected level by mouse bioassay after boiling at $98^{circ}C$ for 10 min and retorting at $115^{circ}C$ for 70 min, while the toxicity of high toxic blue mussel $(E,;8,760{mu}g/100g)$ remained beyond the regulation limit after boiling and retorting at same condition. These results suggested that the regulation limit of PSP could be level up from $(80{mu}g/100g)$ to about $160{mu}g/100g$.