폐의 원발성 림프종은 반응성 림프성 병변과 조직학적으로 감별하기가 어려우나, 반응성 림프증식 증은 polyclonality를 보이는 반면에 악성 림프종은 monoclonality를 보이므로 immunohistochemistry, PCR 분석을 이용하여 감별할 수 있다. 저자 등은 59세 여자 환자에서 개흉폐생검과 lmmunorustochemistry로 진단하고, PCR로 재확인한 악성 B-cell 림프종 1례를 경험 하였기에 문헌고찰과 함께 보고하는 바이다.
The pulmonary lymphomas were thought to originate in specialized lymphoid tissue that is associated with bronchial mucosa(bronchus-associated lymphoid tissue(BALT)), and they were categorized as mucosa-associated lymphoid tissue(MALT) lymphoma. MALT lymphoma consists of a monoclonal population of cell, in contrast to reactive lymphoid proliferation, which consists of polyclonal cells. Lymphoma arising from MALT(=MALToma) represents a distinct clinicopathologic features. It is usually localized 10 their original site for a long time and shows much more favorable prognosis than lymphoma at other site. Some MALT lymphoma could arise simultaneously or successively in different organ or that cells from MALT lymphoma might circulate and give rise to another lymphoma by homing in the MALT of another organ, such as breast, salivary gland, stomach etc, and can be multifocally disseminated or recurred. We report a case of low-grade B-cell lymphoma of the mucosa-associated lymphoid tissue(MALT) of the lung, which was confirmed by open lung biopsy, immunohistochemistry and PCR assay.
