An inclusion complex of muscone with ${eta}-cyclodextrin$ (CD), as a solid form of muscone, was prepared to increase the solubility of muscone. The molar ratio of muscone to ${eta}-CD$ in complex was in the range of $1:1{sim}1:5$ when prepared by freeze-drying method. The interaction of muscone with ${eta}-CD$ in solid state was investigated by Infrared (IR) spectroscopy and differential scanning calorimetry (DSC). IR and DSC studies between $muscone-{eta}-CD$ inclusion complex and physical mixture showed that $muscone-{eta}-CD$ inclusion complex was prepared stably. From the amount of muscone incorporated in the inclusion complex, it was found that the molar ratio of muscone : ${eta}-CD$ was 1:1. Relative spatial position of muscone and ${eta}-CD$ was observed by Hyperchem molecular modelling program.