In order to investigate the effects of Sojeokbaekchoolsan on the various immune responses, the chemotactic and adherent ability of macrophages were studied in vivo and in vitro. The results obtained were follows: 1. The administration of Sojeokbaekchoolsan enhanced significantly the Chemotactic activity of macrophages and neutrophils. 2. The administration of Sojeokbaekchoolsan enhanced significantly the adherent activity of macrophages and neutrophils. From above findings, it is suggested that Sojeokbaekchoolsan seem to produce the increase of immune response such as the chemotactic activity and adherent activity of macrophage. According to the above results, it could be suggested that Jukyeopseokgo-tanggagambang extract has indirect autitumor effects by strengthening the effects of MMC on tumor cells.