Purpose : To evaluate changes of pancreatic size with aging in control subjects and in non-insulin- dependent diabetic patients. Materials and Methods : Two groups of non-insulin-dependent diabetic patients were examined; one had been treated with an oral hypoglycemic agent(n=59), and the other with insulin(n=56). The CT findings of 175 patients without clinical evidence of pancreatic disease were included as a normal control. Results : In control subjects, pancreatic size and age correlated. The pancreas was smaller in non-insulin-dependent diabetics than in control subjects and smaller in insulin-treated non-insulin-dependent diabetics than in non-insulin treated patients. Conclusion : The pancreas was smaller in non-insulin-dependent diabetic patients than in control subjects within the same age range.