The Facile and Efficient Synthesis of 8-Chloroadenosine $3^I,5^I$-cyclic monophosphate by phosphorylative cyclization of 8-chloroadenosine and its characterization by$^1 H and 13^C$ NMR spectroscopy

The Facile and Efficient Synthesis of 8-Chloroadenosine $3^I,5^I$-cyclic monophosphate by phosphorylative cyclization of 8-chloroadenosine and its characterization by$^1 H and 13^C$ NMR spectroscopy
The Facile and Efficient Synthesis of 8-Chloroadenosine $3^I,5^I$-cyclic monophosphate by phosphorylative cyclization of 8-chloroadenosine and its characterization by$^1 H and 13^C$ NMR spectroscopy

ㆍ 저자명: Woo. Nam-Tae,Jin. Sun-Yong,Cho. Dae-Jin,Kim. Nam-Sun,Bae. Eun-Hyung,Jung. Jee-Hyung,Ham. Won-Hun,Jung. Young-Hoon
ㆍ 간행물명: Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
ㆍ 권/호정보: 1997년|20권 2호|pp.176-179 (4 pages)
ㆍ 발행정보: 대한약학회
ㆍ 파일정보: 정기간행물|ENG|
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ㆍ 주제분야: 기타

이 논문은 한국과학기술정보연구원과 논문 연계를 통해 무료로 제공되는 원문입니다.

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기타언어초록

Purine nucleosides were chlorinated by the reaction of acyl chloride in DMF with MCPBA under mild conditions with moderate yields. And, satisfactory method for the synthesis of ribonucleoside-$3^{I},5^{I}$-cyclic phosphates and its characterization by$^{1}H$ and $^{13}C$ nmr spectroscopy is described.

키워드

8-Chloroadenosine-3`5`-cyclic monophosphate antitumor agent antineoplastic drug c-AMP binding site protein kinase isozyme

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