This paper presents the effective technique to design a six-axis load cell by using experimental design with an orthogonal array. A binocular structure is used as a basic sensing element for a load cell instead of the parallel plate structure. The finite element method is adopted to obtain strain distributions of the sensing element, and by doing the analysis of variances, its results are utilized in determining the factor which is more influential to the output strain. Calibration test results show that the developed six-axis loa cell with the maximum capacities of 196 N in forces and 19.6 N. m in moments is evaluated to be useful with the coupling error less than 2.5%.