Pneumoconiosis is the result of the long-continued inhalation of dusts and it depends on the interaction between the man and the cloud to which he is exposed. The health effects of dusts, especially silica dust exposure have been since Egyptians had constructed the pyramids in ancient times. Subsequently, many works, including miners, milers, quarry workers, sandblasters, tunnel drivers, are occupationally exposed to mineral dusts. These workers may develop pneumoconiosis and in some instances, malignant neoplasms, particularly lung cancer, as a result of such exposures.Both quantity and quality of mineral dusts in the lungs show significant correlation with the degree of damage from pneumoconiosis. So mineralogical techniques require in pathological studies and in estimation of the airborne dusts in working places.Mineralogy has played an important role in both branches of the protective procedure. This lecture presents the knowledge on lung dust, cytotoxicity and fibrogenetic activity of minerals and control procedures for pneumoconiosis from pont of mineralogist.