This paper reports the effort for developing this new Unified Manufacturing Instruction Set and its environment, called here UniSet, to deal with difficulties in set up and operation of Flexible Manufacturing Cells, UniSet has been developed as a non-exclusive unified manufacturing instruction set based on com- parisons of the prevailing machine tool and programming primitives. UniSet allows programmers to deal with only one instruction set, if they so desire, in a single coherent enviroment, rather than numerous machine programming languges. The software system is coded in an Object-Oriented Programming (OOP) language, Smalltalk, and derives its paradigm from the OO philosophy. Test results are also includ- ed to demonstrate the applicability of the approach employed.