The dynamic responses of highway bridges are varying depending on the features of either traveling vehicles or bridges. In this study, the probabilistic characteristics of dynamic amplification factors of highway bridges due to traveling heavy vehicles have been examined through analytical simulation processes. The truck with tandem axle and tractor with semitrailer are selected as the representative heavy vehicles, which are modeled with three dimensional 7-DOF and 12-DOF models, respectively. The analytical results have been compared with the experimental results of dynamic loading tests and the validity of the analytical models has been examined. Parametric studies on the means and extreme values of amplification factors have been performed with various traffic conditions such as vehicle types, vehicle weights, surface profiles, number of loading vehicles, loading positions, etc.