Amplication factor spectrum, using the observed strong ground motions database, has been obtained and compared with Standard Response Spectrum. The observed ground motions from the Miramichi, Nohanni, Sagueray and New Madrid Earthquake (19 vertical components, 36 horizontal components), which are estimated to represent domestic seismotectonic characteristics such as seismic sources, attenuation, and site effect, are used for the analysis of amplification factor spectrum. Amplication factors have been calculated by comparing the observed peak ground motions with results form responses to the observed horizontal and vertical ground motions. The comparison shows that the amplification factors resultant from this study exceed those of Standard Response Spectrum of relatively higher frequencies. The result implles that the characteristics of the seismic strong ground motion, which may represent the domestic seismotectonic characteristics differ from of standard Response Spectrum, especillay of higher frequencies