The necessity of a high-rise building in big cities gave a new problem to structural engineers. The shortening effect of vertical members needs special considerstion in the desigh and construction of high-rise buildings. The shortening of each column transfers load to nonstructural members such as partitions, cladding, and M/E systems which are not designed to carry gravity loads. Also, the slabs and beams will tilt due to the cumulative differential shortening of adjacent vertical members. The main purpose of estimating the total shortening of vertical structural members is to compensate the differential shortening between adjacent members. This paper presents the structural effect of differential shortening between in main structural members. Lateral earthquake load is applied to the 52 story concrete structure which has an initial vertical displacement due to the gravity load. Shortening amount for each vertical member was estimated using the computerized column shortening software. Comparison of stresses between the shortening corrected structure and the uncorrecated structure due to earthquake load was discussed.