The measurement of many biochemical changes that could be appeared as aging will be resulted in the very useful and basal marker to maintain healthy life and to predict the health condition and the retardation of the aging. We classified the geriatrics into the normal and same aged dementia on the based of clinical diagnostic as well as MMSE evaluation. And then we were collected blood samples from both groups and examined 13 biochemical assays to screen any valuable biochemical index for dementia. Among 13 assays, several assay data showed the statistically significant differences between two groups. The values of serum albumin, APase, and GOT were significantly decreased in demented group compared to control. On the other hand, the values of glucose and LDH were increased in dementia compared to control. Additionally, the value of Pi was increased but the values of calcium and GPT were decreased, without significant difference (p＞0.05). The values of other assays such as bilirubin, BUN, cholesterol, creatinine and total protein did not show any statistically significant differences. Conclusively it may be suggested that dementia might be resulted in the variable biochemical changes which could be affected by many environmental factors as well as dementia itself.