Laryngomalacia is the most common cause of stridor in infant. It is a relatively benign self-limiting condition, but in severe cases, it results in obstructive sleep apnea, cor pulmonale , gastroesophageal reflux, failre to thrive, pectus excavatum, respiratory failure and death. When the airway obstruction related to laryngomalacia becomes significant, surgical correction of the underlying laryngeal deformity is indicated. Numerous reports provide evidence to support the trimming supraglottic soft tissue by using either conventional instruments or the surgical laser for treatment of severe laryngomalacia. Recently, authors experienced a case of laryngomalacia with Trisomy 13 (Patau syndrome) which had three times respiratory arrest and was treated with laser aryepiglottoplasty. We report this case with review of the literatures.