A numerical procedure for dynamic analysis of structures including lateral-torsional coupling, axial force effect and soil-structure interaction is presented in this study. A simple soil-structure system model has been designed for microcomputer applications capable of reflecting both kinematic and inertial soil-foundation interaction as well as the effect of this interaction on the superstructure response. A parametric study focusing on inertial soil-structure interaction is carried out through a simplified nine-degree of freedom building model with different foundation conditions. The inertial soil-structure interaction and axial force effects on a 20-storey building excited by an Australian earthquake is analysed through its top floor displacement time history and envelope values of structural maximum displacement and shear force.