The purpose of the study is to establish the nurses engaged in blood donation business right cognition and supply base data to make out proper directed blood donation rule through investigation of actual condition and general issue related to directed blood donation. In this study I searched for related reference and computed the directed blood donors in seoul national university hospital blood bank. The directed blood donation in Korea have been increased for supplying fresh whole blood and plateletpheresis donor blood. The most blood donation in the blood bank belong to hospital are directed blood donation. The benefits of directed blood donation are enlargement blood donor, easy insurance a demand type of blood. But that program also give rise to recipient severe burden, additional cost and confused blood donation system. First of all for lessening the burden of the recipient and the directed blood donor, blood donation site, time, cost and procedure must be repared by proper rules. An alternative plans for the directed blood donation are autologous blood program and donor registration system.