- 의치환자에서 Candida albicans분리와 amphotericin B 및 miconazole에 시험관내 감수성
- ㆍ 저자명
- 신무학,김신무,Shin. Moo-Hak,Kim. Shin-Moo
- ㆍ 간행물명
- 대한치과기공학회지
- ㆍ 권/호정보
- 1997년|19권 1호|pp.113-120 (8 pages)
- ㆍ 발행정보
- 대한치과기공학회
- ㆍ 파일정보
- 정기간행물| PDF텍스트
- ㆍ 주제분야
- 기타
Candida albicans is now well recognized among the denture stomatitis patients. The broth macrodilution test is the most widely used technique for antifungal susceptibility testing. The purpose of this study was to determine the C. albicans carrier rate of the denture patients in Iksan, chonbuk. To determine the C. albicans carrier rate of denture patients, culture were made from 227 sample taken in Iksan, Chonbuk during July 1997 to August 1997. Also activities of amphotericin B and miconzole against isolates of denture patients of C. albicans were tested by broth macrodilution test using RPMI medium 1640. The results were as follows : First C. ablicans was isolated from 6.6% of denture patients samples and the frequency of isolation fo C. albicans was highest(50%) in the age group of 71-year-old to 80-year-old denture patients. Second, against C. albicans, the MIC range of amphotericn B was $0.06{sim}0.25{mu}g/ml$. MIC50 and MIC90 were $0.13{mu}g/ml$ and $0.25{mu}g/ml$, respectively. Third, the MIC range of miconazole was $10-{ge}20{mu}g/ml$ and MIC50 and MIC90 were $20{mu}g/ml$ and ${ge}20{mu}g/ml$, respectively. It was concluded from this study that C. albicans acrriages from healthy denture individuals only over 60-year-old ages were isolated, they remain susceptible to amphotericin B and not rarely resistant to miconzole.