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의치환자에서 Candida albicans분리와 amphotericin B 및 miconazole에 시험관내 감수성
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  • 의치환자에서 Candida albicans분리와 amphotericin B 및 miconazole에 시험관내 감수성
저자명
신무학,김신무,Shin. Moo-Hak,Kim. Shin-Moo
간행물명
대한치과기공학회지
권/호정보
1997년|19권 1호|pp.113-120 (8 pages)
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대한치과기공학회
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이 논문은 한국과학기술정보연구원과 논문 연계를 통해 무료로 제공되는 원문입니다.
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기타언어초록

Candida albicans is now well recognized among the denture stomatitis patients. The broth macrodilution test is the most widely used technique for antifungal susceptibility testing. The purpose of this study was to determine the C. albicans carrier rate of the denture patients in Iksan, chonbuk. To determine the C. albicans carrier rate of denture patients, culture were made from 227 sample taken in Iksan, Chonbuk during July 1997 to August 1997. Also activities of amphotericin B and miconzole against isolates of denture patients of C. albicans were tested by broth macrodilution test using RPMI medium 1640. The results were as follows : First C. ablicans was isolated from 6.6% of denture patients samples and the frequency of isolation fo C. albicans was highest(50%) in the age group of 71-year-old to 80-year-old denture patients. Second, against C. albicans, the MIC range of amphotericn B was $0.06{sim}0.25{mu}g/ml$. MIC50 and MIC90 were $0.13{mu}g/ml$ and $0.25{mu}g/ml$, respectively. Third, the MIC range of miconazole was $10-{ge}20{mu}g/ml$ and MIC50 and MIC90 were $20{mu}g/ml$ and ${ge}20{mu}g/ml$, respectively. It was concluded from this study that C. albicans acrriages from healthy denture individuals only over 60-year-old ages were isolated, they remain susceptible to amphotericin B and not rarely resistant to miconzole.